Synonyms: HOPP syndrome | Hypotrichosis-osteolysis-periodontitis-palmoplantar hyperkeratosis syndrome | Hypotrichosis-striate palmoplantar hyperkeratosis-acroosteolysis-periodontitis syndrome | Hypotrichosis-striate palmoplantar keratoderma-acroosteolysis-periodontitis syndrome
Hypotrichosis-osteolysis-periodontitis-palmoplantar keratoderma syndrome is an extremely rare ectodermal dysplasia syndrome characterized by hypotrichosis universalis with mild to severe scarring alopecia acro-osteolysis onychogryphosis thin and tapered fingertips periodontitis and caries leading to premature teeth loss linear or reticular palmoplantar keratoderma and erythematous scaling psoriasis-like skin lesions on arms and legs. Lingua plicata and ventricular tachycardia have also been observed.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version July 2026
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Hypotrichosis-osteolysis-periodontitis-palmoplantar keratoderma syndrome?
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Advocacy Organizations
National Foundation for Ectodermal Dysplasias
Together, we enrich the lives of people affected by ectodermal dysplasias by fostering community, providing education and support, and driving advocacy and groundbreaking research—creating a brighter future for all.
Uganda Alliance of Patients Organization
Supporting patients to access quality, safe and patient-centered healthcare services.
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Clinical Trials
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