Ledderhose disease

Synonyms: Plantar fibromatosis

A rare benign superficial fibromatosis disease characterized by single or multiple uni- or bilateral slow-growing round firm nodules typically located on the medial portion of the plantar aponeurosis with no calcification. Patients are often asymptomatic or may present with foot pain difficulty to walk or stand and rarely toe contractures. Histopathology reveals dense fibrocellular tissue with parallel and nodular arrays of fibrocytes and fibrillar collagen with a distinctive cork-screw morphology and no atypia.