Synonyms: NF1-like syndrome | Neurofibromatosis 1-like syndrome | Nonmosaic LGSS | Nonmosaic Legius syndrome
Legius syndrome also known as NF1-like syndrome is a rare genetic skin pigmentation disorder characterized by multiple café-au-lait macules with or without axillary or inguinal freckling.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version May 2026
Newly diagnosed with
Legius syndrome?
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Advocacy Organizations
RASopathies Network
Our mission is to advance research to improve the quality of life for RASopathy families by bringing together clinicians, scientists, and families.
ReNU2 United
ReNU2 United fosters collaboration, supports families, raises awareness, and advances research into RNU2-2-related neurodevelopmental disease.
Uganda Alliance of Patients Organization
Supporting patients to access quality, safe and patient-centered healthcare services.
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Clinical Trials
For a list of clinical trials in this disease area, please click here.