Synonyms: NF1-like syndrome | Neurofibromatosis 1-like syndrome | Nonmosaic LGSS | Nonmosaic Legius syndrome
Legius syndrome also known as NF1-like syndrome is a rare genetic skin pigmentation disorder characterized by multiple café-au-lait macules with or without axillary or inguinal freckling.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
Newly diagnosed with
Legius syndrome?
Our RARE Concierge Services Guides are available to assist you by providing information, resources and connections as you navigate your rare disease journey.
Advocacy Organizations
RASopathies Network
Our mission is to advance research to improve the quality of life for RASopathy families by bringing together clinicians, scientists, and families.
Don't see your organization here. Let us know here.
Clinical Trials
For a list of clinical trials in this disease area, please click here.
