TAFRO syndrome

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Synonyms: Thrombocytopenia-anasarca-fever-renal insufficiency-organomegaly syndrome

A rare systemic disease characterized by acute or subacute onset of thrombocytopenia anasarca (edema pleural effusion ascites) and systemic inflammation (fever and/or elevated C-reactive protein). Minor diagnostic categories are Castleman’s disease-like features on lymph node biopsy reticulin myelofibrosis and/or increased number of megakaryocytes in bone marrow progressive renal insufficiency and mild organomegaly including hepatosplenomegaly and lymphadenopathy. Most patients show elevated levels of serum alkaline phosphatase while marked polyclonal hypergammopathy is rare.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version June 2024

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TAFRO syndrome?

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Advocacy Organizations

National Center of Hematology and Blood Transfusion

Treatment of patients with blood diseases,scientific-research works

Youth And Women for Opportunities Uganda-YWOU

Our mission supports Rare, orphan and undiagnosed diseases diagnosis, care and treatment, education, awareness and empowering health care professionals and patients care takers of rare, orphan and undiagnosed diseases arena in Uganda, build capacity and bridge lack of clinical knowledge and experience and provide search/quest for diagnostic laboratories, I advocate for changes in laws, practices

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Clinical Trials

For a list of clinical trials in this disease area, please click here.