Synonyms: Adair-Dighton syndrome | Mild osteogenesis imperfecta | Non-deforming osteogenesis imperfecta | OI type 1 | Van der Hoeve syndrome
A mild form of osteogenesis imperfecta (OI) characterized by increased bone fragility and low bone mass that clinically manifests with increased susceptibility to bone fractures (including vertebral crush fractures) normal height or short stature (typically between 0 and -2.0 SD scores) mild (Cobb angle <30 degrees) or no scoliosis blue sclera and in dentinogenesis imperfecta and mild long bone bowing bone deformities.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
Newly diagnosed with
Osteogenesis imperfecta type 1?
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Advocacy Organizations
Osteogenesis Imperfeca Foundation
The mission of the OI Foundation is to improve the quality of life for those living with osteogenesis imperfecta through research, education, awareness, and mutual support.
The Chandler Project
The Chandler Project brings awareness and shines a light on transformative research surrounding achondroplasia and other skeletal dysplasias by offering support to a global community and network of patients, parents, and caregivers seeking information on scientific discoveries, pharmaceutical advancements and surgical treatment options.
Wave of Support, Inc
Empowering those affected by bleeding disorders and other rare disease through advocacy, resources, education, and support
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Clinical Trials
For a list of clinical trials in this disease area, please click here.