Factor VIII deficiency
Hemophilia A, Classic hemophilia
Type of disease: Rare conditions
Hemophilia A is a bleeding disorder that slows the blood clotting process. People with this disorder experience prolonged bleeding or oozing following an injury, surgery, or having a tooth pulled. In severe cases of hemophilia, heavy bleeding occurs after minor trauma or even in the absence of injury (spontaneous bleeding). Serious complications can result from bleeding into the joints, muscles, brain, or other internal organs. Milder forms of hemophilia do not involve spontaneous bleeding, and the disorder may not become apparent until abnormal bleeding occurs following surgery or a serious injury. Hemophilia A is inherited in an X-linked recessive fashion and is casued by mutations in the F8 gene.Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.