Acute generalized exanthematous pustulosis

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Acute generalized exanthematous pustulosis

Synonyms: AGEP | Pustular drug eruption | Toxic pustuloderma

A rare hypersensitivity reaction characterized by the rapid development of numerous nonfollicular sterile pinhead-sized pustules on an erythematous base predominantly occurring on the trunk intertriginous and flexural areas with rare mostly oral mucosal involvement. Fever peripheral blood leukocytosis and mild eosinophilia are accompanying features. Systemic involvement with hepatic renal or pulmonary dysfunction occasionally occurs. Onset usually occurs 1-12 days after administration of the causal medication and is most frequently associated with beta‐lactam antibiotics macrolides (including pristinamycin and clindamycin) diltiazem terbinafine (hydroxy‐)chloroquine but many other medications have also been implicated. Histology reveals spongiform subcorneal and/or intraepidermal pustules but this pattern is not specific (same in pustular psoriasis).

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http: // Data version September 2023.

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