Synonyms: Acute myeloid leukemia, minimal differentiation, FAB M0
A rare acute leukemia of ambiguous lineage characterized by clonal proliferation of primitive hematopoietic cells primarily in the bone marrow and blood lacking lineage-specific markers and detectable genotypic alterations. The patients present with leukocytosis anemia variable platelet count and a variety of nonspecific symptoms related to ineffective hematopoesis (fatigue bleeding and bruising recurrent infections bone pain) and/or extramedullary site involvement (lymphadenopathy splenomegaly hepatomegaly).
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
Newly diagnosed with
Acute undifferentiated leukemia?
Our RARE Concierge Services Guides are available to assist you by providing information, resources and connections as you navigate your rare disease journey.
Advocacy Organizations
Mitchell’s Fund
Founded in 2016 in memory of Mitchell Bays Turner, who lost his life to a rare form of leukemia, Mitchell’s Fund provides targeted mental health services to some of Charlotte's most vulnerable families: those experiencing the trauma of a childhood diagnosis of a terminal or life-threatening illness. Our primary goal is to provide counseling and play therapy to sick children and families at no cost
RUNX1 Research Program
At the RUNX1 Research Program, our mission is to improve the quality of life and prevent cancer in patients with RUNX1-FPD. We do this by promoting awareness and funding world-class collaborative research with an empowered patient community.
Team Telomere
A Community for Telomere Biology Disorders Our mission is to provide information and support services to families worldwide affected by Dyskeratosis Congenita and Telomere Biology Disorders, to encourage the medical community’s research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.
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Clinical Trials
For a list of clinical trials in this disease area, please click here.