Synonyms: APLS | Antiphospholipid antibody syndrome | Classic APLS | Classic antiphospholipid syndrome | Hughes syndrome
A rare systemic autoimmune disease characterized by hypercoagulability with vascular thrombosis and in women pregnancy morbidity (miscarriages severe pre-eclampsia placental insufficiency) in the presence of serum antiphospholipid antibodies such as lupus anticoagulant anticardiolipin antibodies and anti-beta2-glycoprotein 1 antibodies.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version March 2026
Newly diagnosed with
Antiphospholipid syndrome?
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Advocacy Organizations
APS Foundation of America, Inc
Founded in 2005, the APS Foundation of America, Inc. (APSFA) is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research, and patient services for Antiphospholipid Syndrome (APS) in an effective and ethical manner.
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Clinical Trials
For a list of clinical trials in this disease area, please click here.