Synonyms: Subacute myeloid leukemia
A rare myelodysplastic/myeloproliferative neoplasm characterized by peripheral blood leukocytosis due to increased numbers of morphologically dysplastic neutrophils and their precursors hypercellular bone marrow with granulocytic proliferation and dysplasia (with or without dysplasia in the erythroid and megakaryocytic lineages) and prominent dysgranulopoiesis but no or minimal absolute basophilia or monocytosis. Blasts account for less than 20% of leukocytes in the blood and bone marrow. BCR-ABL1 fusion is absent as well as PDGFRA PDGFRB or FGFR1 rearrangement or PCM1-JAK2. Patients may present with signs and symptoms related to splenomegaly anemia or thrombocytopenia. Prognosis is generally poor.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version February 2026
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Atypical chronic myeloid leukemia?
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