Synonyms: B-CLL | B-cell chronic lymphoid leukemia | Small lymphocytic lymphoma
B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma (see this term) and the most common form of leukemia in Western countries affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1) and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss severe fatigue fever (without evidence of infection) and night sweats as well as cervical lymphadenopathy splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia (see these terms). The clinical course is extremely heterogeneous with survival ranging from a few months to several decades.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
Newly diagnosed with
B-cell chronic lymphocytic leukemia?
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Advocacy Organizations
RUNX1 Research Program
At the RUNX1 Research Program, our mission is to improve the quality of life and prevent cancer in patients with RUNX1-FPD. We do this by promoting awareness and funding world-class collaborative research with an empowered patient community.
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Clinical Trials
For a list of clinical trials in this disease area, please click here.