CAR T cell therapy-associated cytokine release syndrome

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Synonyms: CAR T cell therapy-associated CRS | Chimeric antigen receptor-T cell therapy-associated cytokine release syndrome

A rare systemic condition affecting patients undergoing chimeric antigen receptor (CAR) T-cell therapy and characterized by a systemic inflammatory response due to massive activation of leukocytes with subsequent cytokine release. It can present with a variety of signs and symptoms ranging from mild flu-like symptoms (such as fever fatigue headache rash arthralgia and myalgia) to severe life-threatening manifestations including vascular leakage disseminated intravascular coagulation shock and multiple organ failure. Respiratory manifestations are common and range from cough and tachypnea to acute respiratory distress syndrome (ARDS).

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version July 2024

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Clinical Trials

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