A rare primary germ cell tumor of central nervous system characterized by a lesion typically in the region of the pineal gland and the suprasellar compartment composed of cytotrophoblastic elements and multinucleated syncytiotrophoblastic giant cells. Ectatic stromal vascular channels blood lakes and extensive hemorrhagic necrosis are the rule. The tumor usually arises in the second decade of life and predominantly in males. Clinical presentation depends on location and size and includes signs of increased intracranial pressure visual disturbances and endocrine abnormalities. Prognosis is generally poor.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version February 2026
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Choriocarcinoma of the central nervous system?
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Advocacy Organizations
Pediatric Brain Tumor Foundation
Since 1991, the Pediatric Brain Tumor Foundation has led in funding research, supporting families, and advocating for policies to help patients and survivors. As the largest patient advocacy funder, it drives vital discoveries, new trials, and better treatments. Guided by patient and family experiences, PBTF supports families’ needs at every stage, focusing on care of the entire family.
The JDS Foundation
A foundation that specializes in financial support to high risk and terminal cancer patients to assist in treatment, travel expenses, end of life wishes, outreach, and public awareness.
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Clinical Trials
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