Chronic lymphoproliferative disorder of natural killer cells

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Chronic lymphoproliferative disorder of natural killer cells

Synonyms: CLPD-NK | CNKL | Chronic NK lymphocytosis | Chronic NK-cell lymphocytosis | Chronic lymphoproliferative disorder of NK-cells | NK-cell lineage granular lymphocyte proliferative disorder

A rare large granular lymphocyte leukemia characterized by persistent (> 6 months) natural killer cell lymphocytosis in the absence of clinical diagnosis of leukemia/lymphoma autoimmune disease or chronic viral infections. The clinical course is variable but generally indolent. Patients often remain asymptomatic or may present with clinical manifestations including vasculitic skin lesions neutropenic infections musculoskeletal symptoms peripheral neuropathy or splenomegaly.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on Data version April 2024

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My Faulty Gene

My Faulty Gene is a nonprofit organization which provides information and assistance to any individual whose family medical history suggests genetic testing might be helpful in identifying an increased risk of disease due to a genetic mutation. We believe that everyone in need of genetic testing should have access to it.

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My Little Sunshine is a non-profit foundation dedicated to educating people about the importance of fertility preservation and making fertility resources accessible to all.


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Our mission supports Rare, orphan and undiagnosed diseases diagnosis, care and treatment, education, awareness and empowering health care professionals and patients care takers of rare, orphan and undiagnosed diseases arena in Uganda, build capacity and bridge lack of clinical knowledge and experience and provide search/quest for diagnostic laboratories, I advocate for changes in laws, practices

Clinical Trials

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