Synonyms: CLPD-NK | CNKL | Chronic NK lymphocytosis | Chronic NK-cell lymphocytosis | Chronic lymphoproliferative disorder of NK-cells | NK-cell lineage granular lymphocyte proliferative disorder
A rare large granular lymphocyte leukemia characterized by persistent (> 6 months) natural killer cell lymphocytosis in the absence of clinical diagnosis of leukemia/lymphoma autoimmune disease or chronic viral infections. The clinical course is variable but generally indolent. Patients often remain asymptomatic or may present with clinical manifestations including vasculitic skin lesions neutropenic infections musculoskeletal symptoms peripheral neuropathy or splenomegaly.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
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Chronic lymphoproliferative disorder of natural killer cells?
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