Synonyms: CAD | CAS | Chronic cold agglutinin disease | Cold agglutinin syndrome
Cold agglutinin disease is a type of autoimmune hemolytic anemia (see this term) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30°C).
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
Newly diagnosed with
Cold agglutinin disease?
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Advocacy Organizations
Cold Agglutinin Disease Foundation
A non-profit foundation dedicated to creating heathier lives for the CAD community of patients, and committed to educating them, their care partners and the medical profession about this rare disease.
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Clinical Trials
For a list of clinical trials in this disease area, please click here.