Congenital insensitivity to pain-hyperhidrosis-absence of cutaneous sensory innervation

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Synonyms: Congenital absence of pain with hyperhidrosis | Congenital analgesia with hyperhidrosis | Congenital indifference to pain with hyperhidrosis | Congenital insensitivity to pain with hyperhidrosis

A rare hereditary sensory and autonomic neuropathy characterized by congenital insensitivity to pain general hypesthesia diminished temperature sensitivity and hyperhidrosis. Motor function is preserved. Skin biopsy reveals lack of cutaneous innervation except for sensory and autonomic innervation of blood vessels and sweat glands.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on Data version June 2024

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Project CASK

VISION Project CASK believes in a world free of the life limitations and debilitating effects of CASK gene disorders. ​MISSION To accelerate breakthroughs in research to develop treatments and a cure for CASK gene disorders. ​VALUES Collaboration. Transparency. Urgency.

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