Synonyms: Congenital absence of pain with hyperhidrosis | Congenital analgesia with hyperhidrosis | Congenital indifference to pain with hyperhidrosis | Congenital insensitivity to pain with hyperhidrosis
A rare hereditary sensory and autonomic neuropathy characterized by congenital insensitivity to pain general hypesthesia diminished temperature sensitivity and hyperhidrosis. Motor function is preserved. Skin biopsy reveals lack of cutaneous innervation except for sensory and autonomic innervation of blood vessels and sweat glands.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
Newly diagnosed with
Congenital insensitivity to pain-hyperhidrosis-absence of cutaneous sensory innervation?
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Advocacy Organizations
Charcot-Marie-Tooth Association
Our mission … to support the development of new treatments for CMT, to improve the quality of life for people with CMT, and, ultimately, to find a cure. Our vision … a world without CMT. CMTA was started by patients in 1986, and to this day is powered by a community of patients who are engaged in helping carry out and support our mission.
KIF1A.ORG
KIF1A.ORG is a global community dedicated to improving the lives of those affected by KIF1A Associated Neurological Disorder (KAND) and accelerating research to find a cure.
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Clinical Trials
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