Cramp-fasciculation syndrome
A rare genetic neurological disorder characterized by adult onset of peripheral nerve hyperexcitability causing painful muscle cramps and fasciculations in the limbs hyperreflexia stiffness and muscle pain. Other hypersensitivity-hyperexcitability symptoms are asthma gastroesophageal reflux migraine tremor cold hyperalgesia and cardiac conduction defects. Autonomic signs and symptoms neuropathic pain cognitive deficits and anxiety are also observed.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.
Reference: Access aggregated data from Orphanet at Orphadata.
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http: //www.orphadata.org. Data version September 2023.
Newly diagnosed with
Cramp-fasciculation syndrome?
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Advocacy Organizations
Dysautonomia Support Network
Dysautonomia Support Network’s Mission is to provide a Community that Empowers and Supports those impacted by dysautonomia to live their best lives. DSN provides support through community, virtual support group meetings and amazing resources such as Handouts, Handbooks and our Dyscovery Education video series.
Moonshots for Unicorns
Curing single-gene disorders
COMBINEDBrain Inc
COMBINEDBrain is a consortium for outcome measures and biomarkers for neurodevelopmental disorders. We are collaborating to cure rare, non-verbal brain disorders.
Syndromes Without A Name (SWAN) Australia
Provide information, support and advocacy to families caring for a child with an undiagnosed or rare genetic condition.
Neuromuscular Disease Foundation
The Neuromuscular Disease Foundation's (NDF) mission is to enhance the quality of the lives of people living with GNE Myopathy (also known as HIBM) through advocacy, education, outreach, and funding clinical research focused on treatments and a cure.
Association Aux Pas du Coeur
Our organization wants to raise awareness and recognize rare diseases in Côte d'Ivoire. Our mission is to: Raising awareness and campaigning to help with the diagnosis and free therapeutic care of patients. Request and/or contribute to actions relating to the training of the medical profession so that doctors are able to make a final diagnosis and ensure the continuous follow-up of patients. Create a patient registry to establish very precise statistics of rare diseases in Côte d'Ivoire. Create a close-knit patient community. Break the isolation and despair of sick people and their families. Open up to the world and actively contribute to international research aimed at treatments.
Clinical Trials
For a list of clinical trials in this disease area, please click here.