Early-onset autosomal dominant Alzheimer disease

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Early-onset autosomal dominant Alzheimer disease

Synonyms: EOFAD | Early-onset familial autosomal dominant Alzheimer disease | Familial Alzheimer disease

Early-onset autosomal dominant Alzheimer disease (EOAD) is a progressive dementia with reduction of cognitive functions. EOAD presents the same phenotype as sporadic Alzheimer disease (AD) but has an early age of onset usually before 60 years old.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http: //www.orphadata.org. Data version September 2023.

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Early-onset autosomal dominant Alzheimer disease?

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Advocacy Organizations

Youngtimers Inc.

Youngtimers, formed in 2019, is a non-profit that is dedicated to promoting education, community, support, and research to improve the lives of individuals and families with early onset Alzheimer’s disease or dementia. Early onset familial Alzheimer’s disease is a rare genetic form of Alzheimer’s disease caused by the inheritance of autosomal dominant mutations in one of three genes: amyloid precursor protein (APP), presenilin 1 (PSEN1), or presenilin 2 (PSEN2). Unlike the more common sporadic form of Alzheimer’s disease, individuals with these mutations start developing dementia and other disease-related symptoms usually in their 30s-50s. It is estimated that approximately 45,000 individuals are at-risk for this disease globally. Providing support for these patients is not only advantageous to this specific disease community, but the larger Alzheimer’s disease community as well. These patients have proven essential in understanding and elucidating how Alzheimer’s disease develops in the brain and are involved in testing investigational drugs that target Alzheimer’s disease. Helping this community continue to stay engaged in research will ultimately help the rest of the world affected by Alzheimer’s disease.

Genetic Support Network of Victoria

The Genetic Support Network of Victoria is an organisation that supports people living with genetic, undiagnosed and rare conditions and those who support them including community and families, patient support organisations, health professionals and industry. Our vision is our community flourishing and living their best lives.

Clinical Trials

For a list of clinical trials in this disease area, please click here.