Estrogen resistance syndrome
Estrogen resistance syndrome is a rare genetic endocrine disease characterized by estrogen-receptor insensitivity to estrogens and the presence of elevated estrogen and gonadotropin serum levels. Clinical manifestations include absent breast development and primary amenorrhea in association with multicystic ovaries and/or hypoplastic uterus in female patients normal or abnormal gonadal development in male patients and markedly delayed bone maturation persistence of open epiphyses reduced bone mineral density and variable tall stature in both sexes. Glucose intolerance hyperinsulinemia and lipid abnormalities may also be present.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.
Reference: Access aggregated data from Orphanet at Orphadata.
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2024
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Estrogen resistance syndrome?
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