Harlequin syndrome

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Synonyms: Progressive isolated segmental anhidrosis

Harlequin syndrome (HSD) is an autonomic disorder occurring at any age and characterized by unilateral flushing and sweating involving the face and sometimes arm and chest in condition of thermal exercise or emotional stress without sympathetic ocular manifestations. However tonic pupils parasympathetic oculomotor lesion and pre- or postganglionic sudomotor sympathetic deficit can rarely occur.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version July 2024

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Harlequin syndrome?

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Advocacy Organizations

Project CASK

VISION Project CASK believes in a world free of the life limitations and debilitating effects of CASK gene disorders. ​MISSION To accelerate breakthroughs in research to develop treatments and a cure for CASK gene disorders. ​VALUES Collaboration. Transparency. Urgency.

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Clinical Trials

For a list of clinical trials in this disease area, please click here.