Hereditary breast cancer

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Synonyms: Familial breast cancer | Familial breast carcinoma | Hereditary breast carcinoma

A rare genetic malignant breast tumor characterized by early onset breast cancer in association with a germline mutation. Tumors arising in carriers of BRCA1 and BRCA2 mutations differ morphologically and genetically from each other as well as from sporadic breast cancers. Most BRCA1-associated tumors are invasive ductal adenocarcinomas of no special type typically of higher grade than sporadic tumors and more often negative for hormone receptors. In addition more cases with features of typical or atypical medullary carcinoma are seen in these patients. Likewise BRCA2-associated tumors tend to be of higher grade than sporadic ones although their phenotype is similar. They show a low frequency of HER-2 expression.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on Data version July 2024

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Advocacy Organizations

Help Hope Live

Help Hope Live supports community-based fundraising for people with unmet medical expenses and related costs due to cell and organ transplants or catastrophic injuries and illnesses. These efforts play a critical role in helping clients access the care and equipment they need to heal, live, and thrive. Unlock a powerful and safe way to raise funds for medical needs with Help Hope Live. They provide one-on-one fundraising guidance, a customizable Campaign Page, bill pay support, and additional benefits based on their 501(c)(3) nonprofit status.

My Faulty Gene

My Faulty Gene is a nonprofit organization which provides information and assistance to any individual whose family medical history suggests genetic testing might be helpful in identifying an increased risk of disease due to a genetic mutation. We believe that everyone in need of genetic testing should have access to it.

My Little Sunshine Foundation

My Little Sunshine is a non-profit foundation dedicated to educating people about the importance of fertility preservation and making fertility resources accessible to all.


Educate and provide resources to POC with Rare Cancers

Speaking on Cancer Patient Advocacy

We seek to educate all on cancer from the importance of self-advocacy and how to go about doing that, how to advocate for loved ones and friends with cancer, how to work with fellow employees diagnosed with cancer, the basics of cancer, and much more.

The Assistance Fund

The Assistance Fund (TAF) is an independent charitable patient assistance organization that helps patients and families facing high medical out-of-pocket costs by providing financial assistance for their copayments, coinsurance, deductibles, and other health-related expenses. We currently manage more than 90 disease programs, each of which covers all FDA-approved treatment for the disease named in the program. Since 2009, TAF has helped more than 190,000 people access critical treatment for life-threatening, chronic, and rare diseases.

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Clinical Trials

For a list of clinical trials in this disease area, please click here.