Hereditary breast cancer

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Hereditary breast cancer

Synonyms: Familial breast cancer | Familial breast carcinoma | Hereditary breast carcinoma

A rare genetic malignant breast tumor characterized by early onset breast cancer in association with a germline mutation. Tumors arising in carriers of BRCA1 and BRCA2 mutations differ morphologically and genetically from each other as well as from sporadic breast cancers. Most BRCA1-associated tumors are invasive ductal adenocarcinomas of no special type typically of higher grade than sporadic tumors and more often negative for hormone receptors. In addition more cases with features of typical or atypical medullary carcinoma are seen in these patients. Likewise BRCA2-associated tumors tend to be of higher grade than sporadic ones although their phenotype is similar. They show a low frequency of HER-2 expression.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version March 2024

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Clinical Trials

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