Synonyms: Epilepsy due to FCD
Isolated focal cortical dysplasia is a rare genetic non-syndromic cerebral malformation due to abnormal neuronal migration disorder characterized by variable-sized focalized malformations located in any part(s) of the cerebral cortex which manifests with drug-resistant epilepsy (usually leading to intellectual disability) and behavioral disturbances. Abnormal MRI findings (e.g. abnormal white and/or grey matter signal blurred gray-white matter junction localized volume loss cortical thickening abnormal gyral pattern abnormal hippocampus) and variable histopathologic patterns are associated.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version May 2026
Newly diagnosed with
Isolated focal cortical dysplasia?
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Advocacy Organizations
Access to Life NGO
Our mission is to improve the lives of people affected by genetic epilepsies by empowering patients and families, advancing access to diagnosis and treatment, supporting research, and advocating for equitable, patient-centered care in Ukraine in alignment with global rare disease standards.
Genetic Epilepsy Team Australia
Collaboration of research and care
Pediatric Epilepsy Surgery Alliance
Pediatric Epilepsy Surgery Alliance is the only caregiver-led, science-driven nonprofit organization fully dedicated to the community of children who need neurosurgery to treat their medication-resistant seizures. We enhance the lives of children with drug-resistant epilepsy by empowering their families with research, support services, and impactful programs across the lifespan.
Rare Epilepsy Network (REN)
Improving outcomes of people with rare epilepsies through an innovative collaborative infrastructure that drives urgent, patient-centered research, educaiton and advocacy.
Uganda Alliance of Patients Organization
Supporting patients to access quality, safe and patient-centered healthcare services.
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Clinical Trials
For a list of clinical trials in this disease area, please click here.