Synonyms: Histiocytosis X | Langerhans cell granulomatosis
A rare systemic disease characterized by the accumulation (usually organized in granulomas) of macrophage bearing the features of Langerhans cells in various tissues.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
Newly diagnosed with
Langerhans cell histiocytosis?
Our RARE Concierge Services Guides are available to assist you by providing information, resources and connections as you navigate your rare disease journey.
Advocacy Organizations
The Dynamite Foundation Inc
The Dynamite Foundation is on a heartfelt mission: to bring love, hope, and joy to individuals impacted by Histiocytosis around the world We do this through Dynamite the Histio Warrior Dragon™; a handcrafted crochet dragon sent to Histio Warriors in the midst of their battles, and to Angel Families remembering their loved ones through Angel Dynamite.
Don't see your organization here. Let us know here.
Clinical Trials
For a list of clinical trials in this disease area, please click here.