Synonyms: Combined insulin, insulin-like growth factor 1 (IGF1) and epidermal growth factor (EGF) deficiency | Hoepffner-Dreyer-Reimers syndrome | Werner-like syndrome due to combined growth factor deficiency
A rare genetic lipodystrophy characterized by loss of subcutaneous fat layers on the limbs lipodystrophy in the face and trunk and scleroderma-like skin disorders (thickened skin on the palms and soles and skin pigment changes on the limbs and trunk). Additional clinical signs include joint contractures reduced relative body weight a bird-like facial appearance with a beaked nose micrognathia and insulin-resistant diabetes mellitus.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version May 2026
Newly diagnosed with
Lipodystrophy due to peptidic growth factors deficiency?
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Advocacy Organizations
Lipodystrophy United
Our mission is to provide an interactive community, facilitated support, and education for anyone affected by lipodystrophy. We serve as a resource to increase awareness in the general, medical, and insurance communities. We advocate for new patient diagnosis by assisting healthcare professionals in understanding trends, physical attributes, and clinical symptoms to aid treatment and research.
Uganda Alliance of Patients Organization
Supporting patients to access quality, safe and patient-centered healthcare services.
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Clinical Trials
For a list of clinical trials in this disease area, please click here.