Synonyms: Sotos syndrome 2
A rare multisystemic genetic disorder characterized by a characteristic facial features with macrocephaly overgrowth in infancy intellectual disability and behavioral problems including anxieties and aggressiveness.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
Newly diagnosed with
Malan overgrowth syndrome?
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Advocacy Organizations
Malan Syndrome Foundation
The mission of the Malan Syndrome Foundation is to improve the lives of individuals and families affected by Malan syndrome in the global community through support, outreach and research. We aim to provide a broad network of support to families affected by Malan syndrome and help advance access to a diagnosis, promote knowledge development, awareness and sharing of information, explore research pathways to treatments and cures, as well as enhance understanding of Malan syndrome and related disorders.
Oklahoma Rare
To bring together individuals and families impacted by rare diseases in Oklahoma by building community, sharing trusted resources, and promoting thoughtful, solutions-oriented advocacy. We believe in the strength of families, the power of shared experiences, and the importance of ensuring that every Oklahoman - no matter how rare - has a place, a voice, and a path forward.
PPP2CA Pathways
PPP2CA Pathways connects families, shares strength, and supports the research community in the search for answers to Houge-Janssens Syndrome type 3.
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Clinical Trials
For a list of clinical trials in this disease area, please click here.