Mast cell sarcoma is a rare neoplastic disease characterized by locally destructive sarcoma-like growth of a solitary mass composed of atypical mast cells and without systemic involvement. It can affect any organ and the symptoms depend on the location. Cells are medium to large pleomorphic or epithelioid with oval bilobed or multilobulated nuclei sometimes prominent multinucleated giant cells. The disease closely resembles other neoplasms and may share associated markers however the tumor is positive for mast cell tryptase.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
Newly diagnosed with
Mast cell sarcoma?
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Advocacy Organizations
Super T’s Mast Cell Foundation
To increase awareness through resources, education and support for the mast cell diseases community, while also providing financial assistance to patients.
The Mast Cell Disease Society (TMS)
We are dedicated to providing multi-faceted support to patients, families and medical professionals in our community and to leading the advancement of knowledge and research in mast cell diseases through education, advocacy and collaboration.
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Clinical Trials
For a list of clinical trials in this disease area, please click here.