Multisystem inflammatory syndrome in children and adults

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Synonyms: MIS-C/A

A rare systemic disease characterized by a life-threatening hyperinflammatory state several weeks after infection with SARS-CoV-2 predominantly occurring in children. The primary infection is typically mild or asymptomatic and patients are generally previously healthy individuals. Typical presenting signs and symptoms are persistent fever gastrointestinal symptoms mucocutaneous inflammation lymphopenia and high levels of circulating inflammatory markers. Some patients develop severe disease with cardiac involvement hypotension and shock. Presentation is similar in adults although the severity of cardiac dysfunction incidence of thrombosis and mortality may be higher.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on Data version May 2024

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