Synonyms: PPBL | Persistent polyclonal B-cell lymphocytosis with binucleated lymphocytes
Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare generally benign lymphoproliferative hematological disease characterized by: chronic stable persistent polyclonal lymphocytosis of memory B-cell origin the presence of binucleated lymphocytes in the peripheral blood and a polyclonal increase in serum immunoglobulin M (IgM). Patients are most frequently asymptomatic or may present with mild splenomegaly.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
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Persistent polyclonal B-cell lymphocytosis?
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Clinical Trials
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