Primary cutaneous gamma/delta-positive T-cell lymphoma

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Primary cutaneous gamma/delta-positive T-cell lymphoma

Primary cutaneous gamma/delta-positive T-cell lymphoma is a rare usually aggressive subtype of cutaneous T-cell lymphoma characterized by infiltration of the epidermis dermis or subcutaneous tissue by a clonal population of mature gamma/delta positive cytotoxic T-cells. Typically it presents with ulcerating plaques tumors or subcutaneous nodules on the skin of the extremities however frequent involvement of mucosal and extranodal sites (such as the nasal cavity gastrointestinal tract or lungs) is also observed. Cases associated with panniculitis may present with hemophagocytic syndrome (abrupt onset of fever rash cytopenia hepatosplenomegaly and neurological compromise). Infiltration of lymph nodes spleen and bone marrow is uncommon and resistance to multilineage chemotherapy is reported.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2024

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Primary cutaneous gamma/delta-positive T-cell lymphoma?

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Advocacy Organizations

Cutaneous Lymphoma Foundation

Judy Jones, Judith Shea, and Dr. Stuart Lessin, frustrated with the lack of reliable information about cutaneous lymphomas, started the Mycosis Fungoides Foundation (now the Cutaneous Lymphoma Foundation) in 1998 The Cutaneous Lymphoma Foundation is an independent, non-profit patient advocacy organization dedicated to supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

My Faulty Gene

My Faulty Gene is a nonprofit organization which provides information and assistance to any individual whose family medical history suggests genetic testing might be helpful in identifying an increased risk of disease due to a genetic mutation. We believe that everyone in need of genetic testing should have access to it.

My Little Sunshine Foundation

My Little Sunshine is a non-profit foundation dedicated to educating people about the importance of fertility preservation and making fertility resources accessible to all.

SALUS

Educate and provide resources to POC with Rare Cancers

Youth And Women for Opportunities Uganda-YWOU

Our mission supports Rare, orphan and undiagnosed diseases diagnosis, care and treatment, education, awareness and empowering health care professionals and patients care takers of rare, orphan and undiagnosed diseases arena in Uganda, build capacity and bridge lack of clinical knowledge and experience and provide search/quest for diagnostic laboratories, I advocate for changes in laws, practices

Clinical Trials

For a list of clinical trials in this disease area, please click here.