Synonyms: Agnogenic myeloid metaplasia | Idiopathic myelofibrosis | Myelofibrosis with myeloid metaplasia | Osteomyelofibrosis
A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages such as erythrocytes leukocytes and megakaryocytes with variable degrees of megakaryocyte atypia associated with reticulin and/or collagen bone marrow fibrosis osteosclerosis ineffective erythropoiesis angiogenesis extramedullary hematopoiesis and abnormal cytokine expression.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version May 2026
Newly diagnosed with
Primary myelofibrosis?
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Advocacy Organizations
Team Telomere
A Community for Telomere Biology Disorders Our mission is to provide information and support services to families worldwide affected by Dyskeratosis Congenita and Telomere Biology Disorders, to encourage the medical community’s research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.
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Clinical Trials
For a list of clinical trials in this disease area, please click here.