Sporadic adult-onset ataxia of unknown etiology

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Synonyms: Idiopathic late-onset cerebellar ataxia | SAOA

A rare non-hereditary degenerative ataxia disease characterized by a slowly progressive cerebellar syndrome (with ataxia of stance and gait upper limb dysmetria and intention tremor ataxic speech and oculomotor abnormalities) presenting in adulthood (at around 50 years of age) that is not due to a known cause. Extracerebellar symptoms (e.g. decreased vibration sense and absent or decreased ankle reflexes) polyneuropathy and mild autonomic dysfunction may also be present. Mild cognitive impairment has also rarely been reported.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version July 2024

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Sporadic adult-onset ataxia of unknown etiology?

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Advocacy Organizations

National Ataxia Foundation

Ataxia is a rare neurological disease affecting tens of thousands of people in the US and many thousands more around the world. It is progressive, affecting a person’s ability to walk, talk, and use fine motor skills. The National Ataxia Foundation (NAF) was established in 1957 to help persons with Ataxia and their families. Our mission is to accelerate the development of treatments and a cure

Project CASK

VISION Project CASK believes in a world free of the life limitations and debilitating effects of CASK gene disorders. ​MISSION To accelerate breakthroughs in research to develop treatments and a cure for CASK gene disorders. ​VALUES Collaboration. Transparency. Urgency.

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Clinical Trials

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