Synonyms: 2A syndrome | 3A syndrome | 4A syndrome | AAA syndrome | Achalasia-addisonianism-alacrima syndrome | Adrenal insufficiency-achalasia-alacrima syndrome | Allgrove syndrome | Double A syndrome | Quaternary A syndrome
Triple A syndrome is a very rare multisystem disease characterized by adrenal insufficiency with isolated glucocorticoid deficiency achalasia alacrima autonomic dysfunction and neurodegeneration.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
Newly diagnosed with
Triple A syndrome?
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Advocacy Organizations
Adrenal Insufficiency united
Helping find resources and navigating the health system
Charcot-Marie-Tooth Association
Our mission … to support the development of new treatments for CMT, to improve the quality of life for people with CMT, and, ultimately, to find a cure. Our vision … a world without CMT. CMTA was started by patients in 1986, and to this day is powered by a community of patients who are engaged in helping carry out and support our mission.
Global Adrenal Testing Consortium
The Global Adrenal Testing Consortium is a patient-led nonprofit transforming adrenal health through open, collaborative research. We unite patients, clinicians, and researchers to redefine cortisol testing—prioritizing accuracy, accessibility, and community-driven innovation. By setting transparent standards, advocating for FDA approval, and ensuring global access, we empower the adrenal insuffic
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Clinical Trials
For a list of clinical trials in this disease area, please click here.