RARE Daily

Arbor and Ginkgo Collaborate on Precision Gene Editors

December 12, 2023

Rare Daily Staff

Arbor Biotechnologies and Ginkgo Bioworks entered into a collaboration to leverage Ginkgo’s comprehensive Codebase and automated Foundry to jointly optimize Arbor’s novel precision editors.

“Ginkgo’s expertise aligns well with our goals, and their technology will synergize with our in-house capabilities, potentially fueling a faster, more efficient expansion of our toolbox of gene editing technologies,” said Devyn Smith, CEO of Arbor.

Arbor utilizes its computational metagenomic discovery engine and protein engineering expertise to identify and optimize genetic editors with the potential to treat a broad range of genetic diseases. The company said its portfolio of novel gene editors has significant therapeutic potential due to, among other things, their unique protospacer adjacent motifs (PAMs), which may enable access to nearly all sites in the genome; their varied cut types, which can potentially correct a wider range of diseases; their smaller editing technology, which allows the use of additional delivery technologies; and their high specificity, which can enable improved safety profiles.

Ginkgo’s expertise in high throughput exploration of genetic design spaces complements Arbor’s in-house capabilities, and the collaboration is expected to accelerate Arbor’s precision editor optimization campaign through massively parallel library design, automated mammalian cell experimentation and iterative AI-guided protein engineering.

“As we can see from the recent landmark regulatory approval of the world’s first CRISPR-based treatment, the gene editing landscape is rapidly advancing, with continuous innovation and optimization of novel technologies that are revolutionizing the way we consider and address disease,” said Jason Kelly, CEO and co-founder of Ginkgo Bioworks. “This collaboration with Arbor gives us an opportunity to leverage our platform-driven approach to contribute to the gene editing sector’s fast-moving evolution.”

Financial terms of the collaboration were not disclosed.

Photo: Devyn Smith, CEO of Arbor

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