HI-Bio Launches with $120 Million Financing to Advance Therapies for Immune-Mediated Diseases

Rare Daily Staff

Human Immunology Biosciences launched with $120 million in financing and multiple clinical-stage programs for severe immune-mediated diseases.

ARCH Venture Partners and Monograph Capital incubated the company and were joined by Jeito Capital and unnamed institutional investors and family offices in the financing.

Underlying HI-Bio’s clinical pipeline is a toolkit that encompasses human genetics, human immunophenotyping, data sciences, and therapeutic engineering. This discovery toolkit leverages emerging insights from research and development efforts to profile the immune phenotypes that drive IMDs. The toolkit will allow HI-Bio to rapidly advance its programs from early discovery through clinical development and can be applied to virtually all areas of the immune landscape.

Many IMDs stem from the dysfunction of cells that make up the immune system, including plasma cells, neutrophils, mast cells and more. These cells are responsible for critical functions and processes, including, for example, the secretion of antibodies, signaling mediators, tissue repair and allergic responses. HI-Bio’s programs apply a precision medicine approach to target, modulate or deplete these cellular drivers of disease with therapeutics.

Few targeted therapies exist for the autoimmune, allergic, and inflammatory diseases that can together be referred to as IMDs. As much as 4 percent of the world’s population may have one of these diseases, representing an enormous health burden. Conventional therapies are generally broad acting, and do not address the root causes of disease. As a result, many patients with IMDs experience limited relief from their symptoms and may experience unnecessary side effects. More than half of people treated with currently available therapies are not in remission. With such large unmet medical needs remaining, the global therapeutic market for these diseases could reach $150 billion by 2025.

“Immune-mediated diseases represent a landscape where the scale of unmet need and potential patient benefit is truly enormous,” said Travis Murdoch, CEO of HI-Bio.  

Human Immunology Biosciences’ (HI-Bio) clinical-stage assets include felzartamab, an anti-CD38 antibody, and HIB210, an anti-C5aR1 antibody. Felzartamab targets a protein exprssed on the surface of mature plasma cells whose dysfunction is thought to drive several immune-mediated diseases (IMDs). When applied, felzartamab is believed to deplete plasmablasts and plasma cells, resulting in the removal of cells that produce disease-causing autoantibodies. HI-Bio is testing felzartamab for membranous nephropathy (MN) and IgA nephropathy (IgAN), both rare conditions, with potential to be the best-in-class therapy for autoantibody diseases. HIB210 is currently in ongoing phase 1 safety testing, with anticipated studies in IMDs currently being planned.

Felzartamab and HIB210 were in-licensed through a transaction with MorphoSys in June 2022. HI-Bio holds exclusive worldwide rights for felzartamab, with the exception of Greater China, and exclusive worldwide rights except Greater China and South Korea for HIB210. Terms included a 15 percent equity stake in HI-Bio, milestone payments and single- to low- double-digit royalties on net sales. Both programs are believed to hold potential for expansion in multiple other indications in the IMD landscape. In addition to these programs, HI-Bio is advancing discovery programs targeting the dysfunction of mast cells implicated in several undisclosed indications.

Photo: Travis Murdoch, CEO at HI-Bio