Synonyms: Early-onset familial hyperreninemic hypoaldosteronism | Severe aldosterone synthase deficiency
A rare type of familial hypoaldosteronism characterized by early infantile onset of vomiting diarrhea severe dehydration and failure to thrive. Analysis of plasma electrolytes shows hyponatremia hyperkalemia and acidosis. Plasma renin activity is elevated and aldosterone levels are low.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
Newly diagnosed with
Early-onset familial hypoaldosteronism?
Our RARE Concierge Services Guides are available to assist you by providing information, resources and connections as you navigate your rare disease journey.
Advocacy Organizations
Global Adrenal Testing Consortium
The Global Adrenal Testing Consortium is a patient-led nonprofit transforming adrenal health through open, collaborative research. We unite patients, clinicians, and researchers to redefine cortisol testing—prioritizing accuracy, accessibility, and community-driven innovation. By setting transparent standards, advocating for FDA approval, and ensuring global access, we empower the adrenal insuffic
Don't see your organization here. Let us know here.
Clinical Trials
For a list of clinical trials in this disease area, please click here.