IgG4-related dacryoadenitis and sialadenitis

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IgG4-related dacryoadenitis and sialadenitis

Synonyms: Chronic dacryoadenitis and sialadenitis | Mikulicz disease

IgG4-related dacryoadenitis and sialoadenitis (Mikulicz disease) is an IgG4-related sclerosing disease (see this term) characterized by persistent usually painless bilateral enlargement of the lacrimal parotid and submandibular glands associated with elevated levels of serum immunoglobulin (Ig) G4 and with lymphocyte and IgG4-positive plasmacyte infiltration. It predominantly causes mouth and eye dryness but can also affect other organs such as the lungs liver and kidneys and be accompanied by complications such as autoimmune pancreatitis (AIP) retroperitoneal fibrosis and tubulointerstitial nephritis (see these terms).

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http: //www.orphadata.org. Data version September 2023.

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Clinical Trials

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