Synonyms: Autoantibody-negative autoimmune hepatitis | Seronegative AIH
A form of autoimmune hepatitis characterized by the features of classic autoimmune hepatitis (i. e. clinical presentation as acute or chronic cryptogenic hepatitis interface hepatitis on histological examination elevated serum aspartate aminotransferase and alanine aminotransferase levels hypergammaglobulinemia/elevated immunoglobulin G therapeutic response to corticosteroids) in the absence of serum autoantibodies. Clinical manifestations include fatigue malaise arthralgia jaundice at later stages also signs of advanced chronic liver disease such as spider nevi caput medusae splenomegaly ascites and palmar erythema. Presence of concurrent autoimmune diseases is frequently observed.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
Newly diagnosed with
Seronegative autoimmune hepatitis?
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Advocacy Organizations
Biliary Atresia and Liver Care Africa
Biliary Atresia and Liver Care Africa (BALCA) exists to raise awareness, support families, and advocate for better care for children and individuals living with biliary atresia and other liver diseases across East Africa, giving hope, information, and a strong support system while improving access to treatment and aftercare.
Global Liver Institute
To improve the lives of individuals and families impacted by liver disease through promoting innovation, encouraging collaboration, and scaling optimal approaches to help eradicate liver diseases.
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Clinical Trials
For a list of clinical trials in this disease area, please click here.