A congenital X-linked clinical subtype of L1 syndrome characterized by variable spastic paraplegia mild to moderate intellectual disability and dysplasia hypoplasia or aplasia of the corpus callosum. In this subtype hydrocephalus adducted thumbs or absent speech are not observed.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
Newly diagnosed with
X-linked complicated corpus callosum dysgenesis?
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Advocacy Organizations
National Organization for Disorders of the Corpus Callosum
The NODCC has become the leading organization for disorders of the corpus callosum seeking to raise the profile, understanding and acceptance of these disorders through education, networking, advocacy, and being a catalyst for research.
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Clinical Trials
For a list of clinical trials in this disease area, please click here.