Synonyms: Angiofollicular ganglionic hyperplasia | Angiofollicular lymph hyperplasia
A rare lymphoproliferative disorder characterized by involvement of lymph nodes in any part of the body most frequently the mediastinum abdomen neck or spleen and occurring as unicentric idiopathic multicentric or KSHV/HHV8-associated multicentric Castleman disease. Depending on the type patients are most commonly asymptomatic or typically present with systemic symptoms.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
Newly diagnosed with
Castleman disease?
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Advocacy Organizations
Castleman Disease Collaborative Network (CDCN); University of Pennsylvania
The Castleman Disease Collaborative Network (CDCN) is a global initiative dedicated to accelerating research and treatment for Castleman disease (CD) to improve survival for all patients with CD. We work to achieve this by facilitating collaboration among the global research community, mobilizing resources, strategically investing in high-impact research, and supporting patients and their loved ones.
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Clinical Trials
For a list of clinical trials in this disease area, please click here.