Synonyms: Localized Castleman disease
A rare benign lymphoproliferative disorder characterized by involvement of a single lymph node or a group of lymph nodes in one lymph node station (most commonly in the mediastinum neck abdomen or retroperitoneum). Histopathologically it may occur as a hyaline vascular subtype with hyaline-vascular follicles and a fibrotic and hypervascular stroma with sinus compression or a mixed/plasmacytic subtype with dense interfollicular sheets of (usually polytypic) plasma cells extending to the cortex and variably sized lymphoid follicles including some with regressive changes. Clinically most patients are asymptomatic and lesions are detected incidentally.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version February 2026
Newly diagnosed with
Unicentric Castleman disease?
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Advocacy Organizations
Castleman Disease Collaborative Network (CDCN); University of Pennsylvania
The Castleman Disease Collaborative Network (CDCN) is a global initiative dedicated to accelerating research and treatment for Castleman disease (CD) to improve survival for all patients with CD. We work to achieve this by facilitating collaboration among the global research community, mobilizing resources, strategically investing in high-impact research, and supporting patients and their loved ones.
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Clinical Trials
For a list of clinical trials in this disease area, please click here.