Complement component 3 deficiency
Synonyms: C3 deficiency
Complement component 3 deficiency is a rare genetic primary immunodeficiency characterized by susceptibility to infection (mainly by gram negative bacteria) due to extremely low C3 plasma levels. Patients typically present recurrent episodes of sinusitis tonsillitis and/or otitis as well as upper and lower respiratory tract infections (including pneumonia) and skin infections such as erythema multiforme. Autoimmune disease resembling systemic lupus erythematosus and mesangiocapillary or membranoproliferative glomerulonephritis may develop resulting in renal failure.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.
Reference: Access aggregated data from Orphanet at Orphadata.
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2024
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Complement component 3 deficiency?
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