Spastic paraplegia-Paget disease of bone syndrome
Spastic paraplegia-Paget disease of bone syndrome is an extremely rare complex form of hereditary spastic paraplegia characterized by a slowly progressive spastic paraplegia (with increased muscle tone decreased strength in the anterior tibial muscles and hyperreflexia in the lower extremities with Babinski sign) presenting in adulthood associated with Paget disease of the bone. Cognitive decline dementia and myopathic changes at muscle biopsy have not been reported.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.
Reference: Access aggregated data from Orphanet at Orphadata.
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2024
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Spastic paraplegia-Paget disease of bone syndrome?
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Advocacy Organizations
KIF1A.ORG
KIF1A.ORG is a global community dedicated to improving the lives of those affected by KIF1A Associated Neurological Disorder (KAND) and accelerating research to find a cure.
National Ataxia Foundation
To accelerate the development of treatments and a cure while working to improve the lives of those living with Ataxia.
Clinical Trials
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