Overview

Type of disease: Rare conditions

Adams Oliver syndrome is characterized by birth defects involving the scalp, vascular system (blood vessels), and limbs. Symptoms of Adams Oliver syndrome vary greatly from patient to patient but may include missing areas of skin (often on the scalp), limb defects, heart defects, cutis marmorata telangiectatica congenita,  and occasionally pulmonary hypertension and central nervous system abnormalities. The cause of Adams Oliver syndrome is currently unknown. Both genetic and sporadic inheritance have been reported in the medical literature, however in most cases this syndrome is inherited in an autosomal dominant fashion. Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.