Ledderhose disease


Type of disease: Rare conditions

Ledderhose disease is a type of plantar fibromatosis characterized by thickening of the foot’s deep connective tissue. While many individuals with Ledderhose disease do not experience symptoms, over time the condition may progress, causing considerable pain when walking. Repeated trauma, long-term alcohol consumption, chronic liver disease, diabetes, and epilepsy have been reported in association with the development of this condition. Heredity is also a clear factor in many patients. Often, patients with Ledderhose disease also have other fibrosing conditions such as Dupuytren contracture, knuckle pads, or Peyronie disease.   The exact prevalence of Ledderhose disease is unknown, with some studies stating it is rare , and others stating it is a common condition. Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.

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