Miller Fisher syndrome


Type of disease: Rare conditions

Miller-Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-BarrŽ syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. Like Guillain-BarrŽ syndrome, symptoms may be preceded by a viral illness. Additional symptoms include generalized muscle weakness and respiratory failure. The majority of individuals with Miller-Fisher syndrome have a unique antibody that characterizes the disorder. Treatment includes intravenous immunoglobulin (IVIg) or plasmapheresis (a procedure in which antibodies are removed from the blood) and supportive care. Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.

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