Acute myeloid leukemia with t(8;21)(q22;q22) translocation

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Synonyms: AML with t(8;21)(q22;q22) translocation

A rare acute myeloid leukemia with recurrent genetic anomaly disorder characterized by a t(8;21)(q22;q22) balanced translocation cytogenetic abnormality forming a RUNX1-RUNX1T1 fusion gene presenting with morphological characteristics which include myeloblasts with indented nuclei basophilic cytoplasm with a prominent paranuclear hof that may contain a few azurophilic granules prominent and possibly large promyelocytes myelocytes and metamyelocytes easily identifiable Auer rods and more variably bone marrow eosinophilia. Myeloid sarcoma is frequently present at diagnosis. Detection of the t(8;21)(q22;22) translocation is sufficient for diagnosis irrespective of blast count.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version June 2024

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Acute myeloid leukemia with t(8;21)(q22;q22) translocation?

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Advocacy Organizations

Team Telomere

A Community for Telomere Biology Disorders Our mission is to provide information and support services to families worldwide affected by Dyskeratosis Congenita and Telomere Biology Disorders, to encourage the medical community’s research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

Youth And Women for Opportunities Uganda-YWOU

Our mission supports Rare, orphan and undiagnosed diseases diagnosis, care and treatment, education, awareness and empowering health care professionals and patients care takers of rare, orphan and undiagnosed diseases arena in Uganda, build capacity and bridge lack of clinical knowledge and experience and provide search/quest for diagnostic laboratories, I advocate for changes in laws, practices

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Clinical Trials

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