Acute myeloid leukemia with t(8;21)(q22;q22) translocation
Synonyms: AML with t(8;21)(q22;q22) translocation
A rare acute myeloid leukemia with recurrent genetic anomaly disorder characterized by a t(8;21)(q22;q22) balanced translocation cytogenetic abnormality forming a RUNX1-RUNX1T1 fusion gene presenting with morphological characteristics which include myeloblasts with indented nuclei basophilic cytoplasm with a prominent paranuclear hof that may contain a few azurophilic granules prominent and possibly large promyelocytes myelocytes and metamyelocytes easily identifiable Auer rods and more variably bone marrow eosinophilia. Myeloid sarcoma is frequently present at diagnosis. Detection of the t(8;21)(q22;22) translocation is sufficient for diagnosis irrespective of blast count.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http: //www.orphadata.org. Data version October 2023.
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Acute myeloid leukemia with t(8;21)(q22;q22) translocation?
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