Classic hairy cell leukemia

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Classic hairy cell leukemia

Synonyms: HCL-C | Leukemic reticuloendotheliosis

A rare slowly progressive chronic leukemia characterized by presence of abnormal B-lymphocytes (medium sized with abundant irregular pale cytoplasm hair-like cytoplasmic projections/ruffled cytoplasmic border a round or bean-shaped nucleus and absent nucleoli) in the blood or bone marrow spleen and peripheral blood pancytopenia notable monocytopenia and marked susceptibility to infection. The characteristic immunophenotype is CD11c+ CD25+ CD103+ and CD123+ with a BRAF mutation in most cases.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on Data version December 2023

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Classic hairy cell leukemia?

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Advocacy Organizations

Hairy Cell Leukemia Foundation

The mission of the Hairy Cell Leukemia Foundation (HCLF) is to improve outcomes for patients by advancing HCL research and providing education and support to affected individuals. Our organization is guided by patient leadership. Eight of nine board members are HCL survivors, and our programs are designed and implemented with patient input.

My Faulty Gene

My Faulty Gene is a nonprofit organization which provides information and assistance to any individual whose family medical history suggests genetic testing might be helpful in identifying an increased risk of disease due to a genetic mutation. We believe that everyone in need of genetic testing should have access to it.

My Little Sunshine Foundation

My Little Sunshine is a non-profit foundation dedicated to educating people about the importance of fertility preservation and making fertility resources accessible to all.


Educate and provide resources to POC with Rare Cancers

Youth And Women for Opportunities Uganda-YWOU

Our mission supports Rare, orphan and undiagnosed diseases diagnosis, care and treatment, education, awareness and empowering health care professionals and patients care takers of rare, orphan and undiagnosed diseases arena in Uganda, build capacity and bridge lack of clinical knowledge and experience and provide search/quest for diagnostic laboratories, I advocate for changes in laws, practices

Youth and Women for Opportunities Uganda-YWOU

Youth and Women for Opportunities-YWOU an organization that we represent is patient organization re-presentative, patient and institution and individual capacity builder supporting PLWRD’s to obtain diagnosis, treatment and drugs for those suffering consequences of being undiagnosed or misdiagnosed and lack treatment and those who lack precise diagnosis for rare, orphan and undiagnosed diseases preventing PLWRD’s accessing the most adapted care, treatment or surgery, have delayed access to the most appropriate care, treatment or surgery

Clinical Trials

For a list of clinical trials in this disease area, please click here.