Diffuse palmoplantar keratoderma with painful fissures

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A rare genetic isolated palmoplantar keratoderma characterized by non-epidermolytic diffuse hyperkeratotic lesions affecting both the palms and the soles associated with a tendency of painful fissuring. Contrary to the clinical findings histologic examination reveals findings suggestive of keratosis palmoplantaris striata with orthohyperkeratosis featuring widening of the intercellular spaces and disadhesion of keratocytes in the upper epidermal layers.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version July 2024

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