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Synonyms: Darling disease

A rare mycosis characterized by granulomatous inflammation primarily of the lung after inhalation of spores of Histoplasma capsulatum. The severity of clinical disease depends on the immune status of the individual and the size of the inoculum. In immunocompetent persons the infection usually takes a self-limiting and asymptomatic or relatively mild flu-like course. In immunocompromised patients it can become progressive and disseminated involving multiple organs and presenting with fever pneumonia hepatosplenomegaly skin infiltrates and endocarditis among others.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version December 2023

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Clinical Trials

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