Indomethacin embryofetopathy
Synonyms: Fetal indomethacin syndrome
Indomethacin embryofetopathy refers to the manifestations that may be observed in a fetus or newborn when the mother has taken indomethacin a potent prostaglandin inhibitor and tocolytic agent that can cross placenta during pregnancy. Reported adverse fetal/neonatal effects include decreased renal function resulting in oligohydramnios closure of the ductus arteriosus and delayed cardiovascular adaptation at birth. These effects are usually transient and reversible. Indomethacin may also be a risk factor for cerebral injury (periventricular leukomalacia) and necrotizing enterocolitisin preterm infants.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.
Reference: Access aggregated data from Orphanet at Orphadata.
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2024
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Indomethacin embryofetopathy?
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